The need for pharma to deliver better value for money through medication has perhaps never been more pressing. Healthcare costs are rising twice as fast as GDP growth in many countries and, in the US, nearly half of the adult population has at least one chronic illness (1). 

Against this background, it is estimated that half of medications for chronic diseases are not taken as directed (2), and many struggle to continue with their treatment as prescribed.

Evidence indicates that providing targeted support for those chronic patients on treatment can positively impact adherence and outcomes, in turn generating value for health systems through fewer hospitalisations and lower morbidity and mortality rates. The benefit from greater adherence appears to be a win-win, yet in our experience, only a minority of pharma companies are effectively realising the opportunity for patient support. Research shows that only a small proportion of potentially eligible patients are currently using support programmes, primarily due to a lack of awareness regarding their availability. (3)

This article is written by Wavestone’s patient experience experts, exploring how pharma companies can do more for people that are on their treatment, and what practical steps can be taken to get there.

What is the case for patient support delivered by pharma?

Services that deliver meaningful change for patients go beyond basic access and education resources to deliver interventions that address the holistic needs of the individual. These services are often delivered within a formalised patient support programme (PSP) which we define as a coordinated set of interventions that are aimed at improving outcomes and experience.

Depending on the disease and treatment journey, key components of PSPs could include emotional care and counselling, adherence training & assistance, lifestyle & nutrition advice, symptom & side effect tracking and remote monitoring solutions – all potentially delivered in a synchronised, interactive and personalised way.

The case for actively providing these services revolves around 3 main ideas:

Patient beliefs, attitudes, and preferences regarding healthcare, treatment options, and lifestyle choices play a significant role in treatment adherence and engagement, which in turn impact on outcomes. 

It is critical to see the person behind the patient. This is the only way to truly understand the complex mix of physical, emotional and social challenges someone living with a chronic condition encounters on a daily basis. These challenges can significantly impact quality of life and ability to adhere to, and persist with, the treatments prescribed to them”. Dr Nicola Davies, Behavioural Scientist and patient support expert.

These challenges vary at an individual level and are often further impacted by societal factors that differ across borders. Factors such as health literacy, support networks including family centricity and social stigma of some diseases, play a greater role in some countries than in others. 

Organised Patient Support Programmes (PSPs) provide the means for pharma companies to address individual needs in a coordinated way, with the more sophisticated organisations timing the support according to the individual, with delivery at the precise moment they need it.

There is growing evidence that PSPs can have a positive impact on patient experience and clinical outcomes. Here are five examples:

Pharma has the advantage over other players (new tech companies, health care providers, patient organisations) of truly understanding their medications and treatment journeys. 

As such, they are arguably best placed to design programmes of support that complement – not impinge upon – health provision and positively impact on outcomes. And, unlike national governments, big pharma has the advantage of being able to deliver patient-focused services internationally.

There is additional value to be gained beyond better patient outcomes: deeper patient insights, real world evidence, improved patient centricity, reputation and ultimately improved bottom line through greater treatment persistence.

“Traditionally, holistic patient support is often not seen as the ‘space’ for pharma companies, but they are in the unique position of having the expertise, capability and incentive to deliver impactful improvements – many are already doing it.” Magnus Franzen, patient outcomes & experiences expert. 

Delivering patient support effectively – 6 practical recommendations

Despite the investment, there are many examples of patient support solutions that fall short of making a difference and often centre around single solutions such as apps or educational websites. 

By contrast, we have seen that integrated programmes based on need really can positively impact on patients. Drawing on our experience across multiple big pharma, we make six recommendations to avoid common pitfalls and effectively deliver patient support:

1. Establish the purpose & business value first: Spend time defining the challenge and the desired outcomes. Define the potential value for all stakeholders, while acknowledging the barriers and complexities that lie ahead, and do this long before solutions are introduced. Once the ‘why’ is agreed upon, then discussions with leadership and key functions become consistent, rather than dominated by compliance and ROI challenges.
2. Identify addressable patient beliefs & behaviours: Research and evidence the underlying patient needs and identify the challenges that may impact on their ability to benefit from treatment. Gaining the HCP view on how best to complement their practice and what their expected outcomes are will be important too.  Only when this is all done, should you start considering solutions – the trap of starting with the (usually digital) solution remains all too common!
3. Tailor the design for the local market: Acknowledge the different levels of health system provision and support needs per market. Identify a few pilot market archetypes to co-create with – this will help to create a standardised, above-country patient support ‘menu’ which can be tailored to local needs.
4. Deploy a strategy to communicate the programme: Often left to local markets, the communication strategy should be designed early so that HCP and patient awareness of the available support (and its value) is maximised. In practice, we have seen that when a PSP is integrated into the product’s brand strategy, it is less likely to be seen internally as a separate value-add that may become deprioritised over time.  And by contrast, where there is no coordinated communication effort, especially to HCPs, it is not uncommon to see a take-up of less than 5% of patients on treatment.
5. Consider real world evidence from the start: Data collection is clearly not the primary purpose of PSPs. However, this doesn’t mean RWE should only be seen as an ancillary benefit over the long-term. In fact, leading pharma organisations have transparent data strategies, with the clear rationale of using the data to build up evidence to support care pathway transformation.
6. Consider the enterprise model: Whereas traditional PSPs are often deployed as bolt-on initiatives to brand plans, next generation PSPs require a more comprehensive, patient-centric approach (9). Think ‘above brand’ – while patient support interventions clearly need to be tailored to individual medications and patients, the ‘framework’ that service options are drawn from can be the same. Not only does this provide economies of scale but it also provides both patients and HCPs with a consistent experience.

Let us know if you have a different perspective on this, and how pharma could do more for patients:

Glen McCracken: Patient services specialist

Magnus Franzen-Rossi: Patient outcomes & experiences expert

Sharon Yau: Patient solutions design & execution expert

  1. Raghupathi (2018). An Empirical Study of Chronic Diseases in the United States: A Visual Analytics Approach to Public Health https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876976/ 
  2. Fernando-Lazaro et al (2019). Adherence to treatment and related factors among patients with chronic conditions in primary care: a cross-sectional study Adherence to treatment and related factors among patients with chronic conditions in primary care: a cross-sectional study | BMC Primary Care | Full Text (biomedcentral.com); 
  3. Fierce Pharma (2021). Pharmas’ return on $5B spent yearly on patient support programs? https://www.fiercepharma.com/marketing/pharmas-return-5-billion-spent-yearly-patient-support-programs-only-3-use-survey 
  4. Sacristán et al (2022). The Impact of Patient Support Programs in Europe: A Systematic Literature Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584873/
  5. Marshall et al (2018). Impact of the Adalimumab Patient Support Program’s Care Coach Calls on Persistence and Adherence in Canada: An Observational Retrospective Cohort Study https://pubmed.ncbi.nlm.nih.gov/29519714/
  6. Bessette et al (2018) Impact of the Adalimumab Patient Support Program on Clinical Outcomes in Ankylosing Spondylitis: Results from the COMPANION Study Impact of the Adalimumab Patient Support Program on Clinical Outcomes in Ankylosing Spondylitis: Results from the COMPANION Study | Rheumatology and Therapy (springer.com)
  7. Brixner et al (2019). Patient Support Program Increased Medication Adherence with Lower Total Health Care Costs Despite Increased Drug Spending Patient Support Program Increased Medication Adherence with Lower Total Health Care Costs Despite Increased Drug Spending | Journal of Managed Care & Specialty Pharmacy (jmcp.org)
  8. Khrystolubova et al (2020). Pharmacist-led patient education and adverse event management in patients with non-small cell lung cancer receiving afatinib in a community-based, real-world clinical setting: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886115/pdf/10.1177_1078155219833441.pdf 
  9. M. Franzen-Rossi. From adherence to outcomes: The Patient Support Programme of the future: https://wwa.wavestone.com/en/insight/from-adherence-to-outcomes-the-patient-support-programme-of-the-future/